Circular RNA circDDX17 suppression to gastric cancer progression via the sponging miR-1208/miR-1279/FKBP5 axis encodes a novel circDDX17-63aa protein

Mounting evidence indicates that circular RNAs (circRNAs) are dysregulated in human gastric cancer (GC). The downregulation of circDDX17 is linked to GC progression. However, the role and specific mechanism of circDDX17-mediated GC progression remains elusive. Herein, we report that the downregulation of circDDX17 was correlating with tumor growth and lymph node metastasis in patients with GC. CircDDX17 inhibited GC cell proliferation, migration, and epithelial-mesenchymal transition (EMT) while promoting apoptosis both in vitro and in vivo . Acting as a sponge for miR-1208 and miR-1279, circDDX17 regulated FKBP5 expression in GC cells. FKBP5, in turn, interacted with ERK1/2, influencing GC development through the ERK1/2 pathway. What is more, circDDX17 encoded circDDX17-63aa, which inhibited GC cell proliferation, migration, and EMT. In sum, CircDDX17 exhibits low-expressed in GC via the miR-1208/miR-1279/FKBP5 axis and circDDX17-63aa.