Profiling Expression of Brac2 Gene in Cases of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders-a Pilot Study.

Oral Potentially Malignant Disorders (OPMD) are heterogenous mucosal lesions of oral cavity, which when compared to their normal and other diseased counterparts, are prone to have increased probability/ risk of transformation to malignancy i.e. Oral Squamous Cell Carcinoma (OSCC). Once diagnosed, they pose challenge because of the intrinsic potential to develop into OSCC. So, for a proper follow-up and continued monitoring of such lesions, a common marker which could be applied on the tissues presents itself in results microscopically in such a way that is not only precise and accurate for the prediction of transforming rate, but also draws instant attention to the lesion to halt the progression and prevent further morbidity and financial constraints. Carcinogenesis is a multi-step, multi-gene, and multi-stage complex process involving the oncogene activation and inactivation of tumour suppressor genes. Thereby, not only knowing and the genes is important for diagnosis, but also the molecular pathogenesis and the protein formation underlying disease progression is important, which would help not only in knowing the disease process, but also to identify and prevent the disease beforehand to improve patient’s life outcomes. Thereby, this study identified the expression of tumour suppression gene (TSG), BRAC2 gene, in cases of both OSCC and OPMDs. The results showed that with increased grade and severity of the lesion, the expression of this gene was not seen in either category of the lesions. Thereby, we conclude that a large no of sample size study would be the need to confirm the findings.