Genetic Factor in the Risk of Human Breast Cancer

In this article, we use multistage models to simulate the data of surveillance, epidemiology, and end results (SEER) registry. The data are age-specific incidence rates of breast cancer of females in the United States. Our results indicate that the proportion of the mutation carriers of breast cancer genes is 16% and the proportion of the non-mutation carriers of breast cancer genes is 84%, and 2 gene mutations are most likely to occur in the development of the mutation carriers of breast cancer genes. In addition, the genetic components in the younger is higher than that in the older groups, which is in accordance with observations that the genetic effects are strongest in early-onset cancers.