A case of infantile hepatoblastoma with extramedullary hematopoiesis

Objective : Analysis of clinical and pathological characteristics and prognostic factors of infantile hepatoblastoma with extramedullary hematopoiesis. Method : By analyzing the clinical, imaging, pathological morphology, and immunophenotype characteristics of a case of infantile hepatoblastoma, the histological classification of the tumor, postoperative adjuvant treatment methods, and prognostic factors were discussed. Result: In this case, the tumor was composed of solid cell clusters or nests of immature liver cell tissue of small to medium size.Endothelial cells were found in the stroma, and extramedullary hematopoiesis was easily observed.The immunohistochemical results showed that the tumor cells were partially positive for AFP expression, βcatenin The mixed expression of catenin in the nucleus, cell membrane, and cytoplasm is positive, and INI-1 is positive. TdT and CD71 are positive in extramedullary hematopoietic tissue. Morphological and immunohistochemical analysis shows that this case is a complete epithelial hepatocellular carcinoma, mixed embryonic fetal type. After complete surgical resection, there is no distant metastasis.The COG Evans staging system is stage Ib, and the clinical risk group is classified as low-risk group. Conclusion: The comprehensive treatment of complete surgical resection and chemotherapy can achieve good long-term prognosis in the low-risk group of infantile hepatocellular carcinoma.