Tilte：SNRPA may mediate transcription and splicing of genesassociated with HCC via binding special RNAs
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Small nuclear ribonucleoprotein polypeptide A (SNRPA) was screened as an important RNA-binding protein based on its correlation with survival in Hepatocellular carcinoma(HCC) patients. SNRPA-overexpressed model was established in HepG2 cells. RNA-seq analysis revealed extensive differentially expressed genes (DEGs) expression profiles and the occurrence of regulated alternative splicing events (RASEs). Furthermore, we employed iRIP-seq and integrated the resulting data with RNA-seq data to identify SNRPA-binding RNAs, including CEMIP, SLC4A11, and GTF2IP7. SNRPA also binds and modulates alternative splicing(AS) of genes including RNA splicing, DNA transcription, and cell division, including HNRNPH1, EIF4A2, PPP6R2, FN1, and GNAS. These discoveries creatively reveal the potential molecular regulatory mechanisms of SNRPA in HCC, thereby significantly contributing to the progress and enhancement of research and treatment strategies for HCC.
