The causal relationship between sleep characteristics and skin pigmentation abnormalities based on two-sample Mendelian randomization

Objective To study whether there is a causal association between sleep characteristics and abnormalities of skin pigmentation (Skin pigmentation). Methods Two-sample Mendelian randomization method (MR) using published genome-wide association studies to obtain related exposure factors (SNPs) of sleep characteristics (sleep type, sleep duration) as instrumental variables, MR-gger, weighted median, inverse variance weighted (IVW) random effect model to study the causal effect of sleep characteristics on the risk of skin pigmentation, and MR-Egger sensitivity analysis to verify the reliability of the data. Results: There is a causal relationship between sleep type and abnormal skin pigmentation, different from intermediate type, with obvious preference characteristics: early go to bed, early or late onset will significantly increase the risk of skin pigmentation as a risk factor for skin pigmentation. [IVW random effect model: OR = 1.026,95%CI (1.011,1.041), P =0.001, P <0.05]. However, there was no causal relationship between skin pigmentation and sleep duration. Conclusion: Sleep time type (early / late) may increase the incidence of skin pigmentation, with sleep type (early / late) and skin pigmentation.