Phenolic monoterpene Bakuchiol ameliorates age related Parkinsonism

The phenomenon of aging comes with various spontaneous physiological changes including structural, functional, molecular and cellular. whereas, deterioration from the normal physiology brings chronic changes associated with several neurodegenerative disorders. Neurodegenerative diseases related to aging are the most concerned topic due to their devitalizing conditions with lack of therapy options that simultaneously affects the economic and social status. In our study we illustrated the longevity and anti-parkinsonism activity of Bakuchiol (BAK), a phytomolecule from Psoralea corylifolia. Our result showed BAK elevate mean life span up to 38% along with the enhanced survival rate under stress. Additionally, BAK reduces ROS level via boosting anti-oxidant level through upregulating expression of anti- oxidative genes sod-3 and gst-4 . Remarkably, BAK exhibits neuroprotective effects by attenuating α-synuclein levels. These findings suggest that, in addition to its antioxidant and lifespan-extending properties, BAK positively regulates neurological health. In summary, our study establishes the potential curative effects of BAK on age-related neurodegenerative disorders, positioning it as a promising nootropic drug in modern medicine with broader implications for age-related neurodegeneration.