Analysis of prognostic-related risk factors in ovarian clear cell carcinoma

Objective To analyze the clinical characteristics of patients with ovarian clear cell carcinoma and to explore the prognostic-related risk factors. Methods We retrospectively analyzed 102 patients diagnosed with ovarian clear cell carcinoma (OCCC) in Fujian Cancer Hospital from January 2007 to December 2018. Progression-free survival time (PFS) and overall survival time (OS) were estimated by Kaplan-Meier curve, and Cox proportional hazards regression analysis were summarized for the clinical outcomes. Results The median follow-up time of 102 patients was 89.62 months. The 5-year overall survival (OS) and progression-free survival (PFS) were 59.2% and 50.0%. Cox regression univariate analysis showed that stages, concurrent endometriosis, chemotherapy, standardized treatment, platinum chemoresistance, CA-125 normalization, the last CA125 ≤ 20U/ml, and venous thrombosis were associated with OS and PFS ( P <0.05). The lymph node status was only related to OS ( P <0.05). Multivariate analysis showed that stage (HR = 3.475, 95%CI: 1.559–7.744, P  = 0.002), standardized treatment (HR = 0.298, 95%CI༚0.137–0.648, P  = 0.002) and platinum resistance (HR = 9.325, 95%CI༚4.076–21.334, P< 0.001) were independent prognostic factors for OS. Standard treatment (HR = 0.347, 95%CI༚0.161–0.750, P =  0.007) and platinum resistance (HR = 62.709, 95%CI༚18.687-210.431, P< 0.001) were independent prognostic factors for PFS. Conclusion Stage ,platinum resistance and platinum-based chemotherapy are important prognostic factors in patients with ovarian clear cell carcinoma. CA125 levels ,endometriosis, lymph node status and venous thrombosis are also associated with prognosis.