Association between triglyceride glucose body mass index and left ventricular systolic synchronicity in patients with type 2 diabetes

Background: The triglyceride glucose-body mass index (TyG-BMI) is considered to be an alternative indicator of insulin resistance (IR) with greater clinical value in terms of cardiovascular risk. However, the relationship between TyG-BMI and left ventricular asynchrony, which determines heart function, is unclear. The purpose of this study was to explore the association between the TyG-BMI and left ventricular asynchrony in patients with type 2 diabetes. Methods: This cross-sectional study included 614 patients with type 2 diabetes between September 2021 and June 2023. All patients initially screened with conventional echocardiography underwent subsequent evaluations, including speck-tracking echocardiography and real-time three-dimensional echocardiography. The systolic dyssynchrony index (SDI) was automatically derived from real-time three-dimensional echocardiography in order to assess the degree of left ventricular asynchrony among patients. The TyG-BMI was calculated, and the included patients were stratified according to TyG-BMI quartiles. Results: The analysis of the 614 patients with type 2 diabetes who were ultimately included revealed that the SDI tended to increase as the TyG-BMI increased, with the SDI corresponding to the highest quartile being the highest. According to multiple linear regression analysis, the TyG-BMI is independently related to the SDI. Further exploratory subgroup analysis revealed that the TyG-BMI was more likely to be associated with SDI in patients ≤55 years of age with type 2 diabetes. Conclusions: Our research revealed that the TyG-BMI of patients with type 2 diabetes was positively correlated with the SDI, and this correlation was more obvious in patients with type 2 diabetes who were ≤55 years old.