Association between sleep disorder and gallstone in US adults：Data from NHANES 2017-2020

Sleep disorder is acknowledged as a risk factor for poor health. However, the effect of sleep disorder on the prevalence of gallstones is still unknown. Therefore, we investigated the relationship between sleep disorders and the prevalence of gallstones among National Health and Nutrition Examination Survey participants. Multivariate logistic regression indicated that snore, trouble sleeping, and overly sleepy were an independent risk factor for gallstones. Compared to never snore, 3–4 nights a week and 5 or more nights a week were linked with a higher risk of gallstones prevalence (OR1: 1.47, 95% CI: 1.16–1.87; OR2: 1.38, 95% CI: 1.09–1.75). We also observed that the risk of gallstone formation increased by 1.67-fold in the trouble sleeping group compared to that in the control group (OR:1.67, 95% CI: 1.42–2.01). Furthermore, the correlations appeared to be higher for individuals with overly sleepy (2–4 times a mouth: OR: 1.31, 95% CI: 1.01–1.71; 5–15 times a mouth: OR: 1.50, 95% CI: 1.12–2.01). Thus, our results indicated that sleep disorder is a risk factor for gallstone prevalence.