Blood-triggered Efficient Self-sealing and Tissue Adhesive Hemostatic Nanofabric

Current hemostatic fabric often encounters the issue of blood seeping or leaking through the fabric and at the junctions between the fabric and tissue, leading to extra blood loss. Herein, we developed an efficient hemostatic nanofabric composed of anionic and cationic nanofibers through a double-coaxial electrospinning technique. Upon contact with wound, the porous nanofabric can absorb the interfacial blood and self-seal to form a compact physical barrier through interfiber bonding, preventing blood from longitudinally penetrating the fabric. Moreover, this nanofabric exhibits strong tissue adhesiveness, inhibiting blood seeping out at the seam of the fabric and tissue. Its hemostatic performance in animal injuries surpasses that of standard cotton gauze and Combat Gauze ^TM . In the pig femoral artery injury, the blood loss from the nanofabric was only ca. 8% of that from Combat Gauze ^TM . This nanofabric exhibited antibacterial property, excellent biocompatibility, and promotes wound healing. Our work demonstrates that this strategy for designing hemostatic fabric has great potential.