Television time raised the fasting plasma glucose in non-diabetes population: evidences from NHANES and Mendelian randomization study

Aim: A limited number of studies have explored the association between watching TV and blood glucose in non-diabetic populations using epidemiological databases and mendelian randomization methods. Method: We downloaded the epidemiological database from the website of the National Health and Nutrition Examination Survey, and identified two exposure GWAS datasets, "ukb-a-5" and "ukb-b-5192", along with two outcome GWAS datasets, "ieu-b-114" and "ebi-a-GCST90002232", to investigate the causal relationship between watching TV time and fasting plasma glucose (FPG). Results: The epidemiology database revealed a positive association between watching TV time and FPG and HbA1c levels. Even after adjusting for some covariates, this positive link remained significant (P <0.001). According to the recognized inverse variance weighted (IVW) method, our study indicated the causal relationship between watching TV and FPG level. Conclusion: The association between watching TV and FPG levels is not only evident in epidemiological data but also demonstrates a causal relationship at the GWAS level. These findings suggest the importance of monitoring physical activity levels in non-diabetic individuals to prevent the onset of diabetes.