Laparoscopic sleeve gastrectomy and laparoscopic sleeve gastrectomy with jejunojejunal bypass surgery in patients with obesity: a correlation analysis between body weight, inflammation, glucose metabolism, and sex

Background Bariatric surgery, which can be performed via laparoscopic sleeve gastrectomy (LSG) or laparoscopic sleeve gastrectomy with jejunojejunal bypass (LSG + JJB), is a promising treatment for patients with obesity. However, the influencing factors in LSG and LSG + JJB surgery remain unclear. Methods This study included 60 patients with obesity, divided randomly into LSG group and LSG + JJB group based on the surgical type. The weight loss and diabetes remission were compared at 3 months after surgery. Blood glucose metabolism indices including fasting blood glucose (FBG), homeostatic model assessment of insulin resistance (HOMA-IR), glycated hemoglobin (HbA1c), as well as inflammatory factors were measured. Results We found that the hypoglycemic effect in the LSG + JJB group was significantly superior to that in the LSG group. In the LSG + JJB group, weight was associated with inflammatory factors, including IL-8 (r = 0.431, P = 0.017), TNF-α (r = 0.381, P = 0.038), IL-10 (r = 0.410, P = 0.024), and glucose metabolism indicators FBG (r = 0.360, P = 0.050) and HOMA-IR (r = 0.374, P = 0.042). In addition, we observed a correlation between inflammatory factors and glucose metabolism in this group. The operative effect was also found to correlate with sex; males showed a more optimal effect in decreasing glucose metabolism and reducing inflammatory factors than females who underwent LSG + JJB surgery. Conclusion LSG + JJB surgery was related to inflammation, glucose metabolism, and sex, providing valuable insights for effective treatment approaches targeting individuals with obesity.