Comparative study of brain functional imaging of brain in patients with mild to moderate Alzheimer's disease based on functional near infrared spectroscopy

Objective: Based on the near-infrared functional brain imaging system, this research studied the hemoglobin concentration signal in resting state and task state. The purpose of this research was to analyze the activated brain regions and functional connections by exploring the changes in hemoglobin concentration and the differences in brain network functional connections between healthy people and mild to moderate AD patients. So as to identify the cognitive dysfunction of patients at an early stage. By accurately locating the area of cognitive impairment in patients, it provides a basis for precise neural regulation of physical therapy. Methods: Patients who came to our hospital from January 2022 to December 2022 were recruited and selected according to the exclusion criteria. After receiving their informed consent, MMSE scale examination and near-infrared brain function imaging examination were performed in a relatively quiet environment. Result: Results from 24 subjects of experiment show that 1. In rest state, the function network connectivity of prefrontal decreased in AD patients. 2. The activation of dorsolateral prefrontal lobe and frontal pole decreased in AD patients in VFT task state. 3. The left dorsolateral prefrontal lobe may serve as a key site for early recognition of cognitive decline and non-invasive neuroregulation.