The design of a smart polymeric nanocarrier system linked to Polyamidoamine dendrimer (PAMAM) in fluorouracil drug delivery

In this study, a new platform has been developed and characterized to address the challenges in cancer treatment using the commonly employed anticancer drug 5-Fluorouracil (5FU). Polyamidoamine dendrimer (PAMAM) was grafted to poly (N-isopropyl acrylamide), a temperature-sensitive polymer, and the drug was encapsulated with ethylene glycol dimethyl acrylate (EGDMA). The performance of the synthesized nanocarrier was evaluated using techniques like nuclear magnetic resonance spectroscopy (1HNMR), Fourier transform spectroscopy (FT-IR), ultraviolet-visible spectrometer (UV-vis), and thermal analysis (TGA-DTA). Scanning electron microscope (SEM) images revealed that the nanocarrier maintained a spherical shape ranging from 45–65 nm even after drug attachment. The results demonstrate a significant enhancement in the release profile behavior of this system compared to previous ones. Despite its temperature sensitivity, the system exhibited increased half-life, improved bioavailability at lower concentrations, and reduced toxicity, thereby enhancing the drug's efficacy and improving its application in drug delivery systems.