The cost-effectiveness of an environmental intervention on Carbapenem-resistant Klebsiella pneumonia healthcare-associated infection control

Background Environmental disinfection is important prevention and control measures for CRE. Aim Conducted environmental intervention on CRKP to evaluate the effect and cost. Methods During pre-intervention phase, monitored disinfection effect of environment around patients randomly through microbiological tests quarterly and feedback to supervise environment disinfection. During intervention phase, targeted microbiological monitoring disinfection effect of environment around CRKP patients, used multiple monitoring methods including fluorescent labelling, ATP to strengthen monitoring. Compared CRKP HAI rates and surroundings monitoring qualification rates, calculated the increased cost and effect. Results 44 CRKP positive patients were included from January 2018 to June 2019. CRKP HAI rate decreased from 6.49/1000 admissions in pre-intervention phase to 3.08/1000 in intervention phase, microbiological monitoring qualification rate increased from 79.09% to 90.50%. Total environmental intervention cost was CNY6211.00. CRKP HAI and death cases decreased 3.33, 2.50 respectively. Increased CNY1865.17 environmental intervention cost could prevent one CRKP HAI case, increased CNY2,484.40 cost could reduce one CRKP death case. Conclusion CRE infection is persistent threat. Environmental intervention could be cost-effectively measure.