Identification of Therapeutic Potential of Triazole Antifungal Drugs in Psoriasis using Network Pharmacological Approach
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Psoriasis (PSO) is a chronic immune-mediated skin condition characterized by abnormal keratinocyte growth and inflammation. Clinical occurrences have hinted to a potential connection between fungi and psoriasis as several Malassezia species and Candida Albicans species have been linked to distinct psoriasis subtypes. Triazoles Antifungal drugs have been used mainly to treat Fungal diseases. In this study, we intend to find out different target mechanism pathway through which triazoles drugs can act in the pathophysiology of psoriasis by Network pharmacology approach. Utilizing Swiss Target Prediction, GeneCard, Pharmmapper, Venn diagram analysis, String database, and Cytoscape, the study identified 76 mutual targets out of 4492 for psoriasis and 294 for triazole derivatives. The PPI network highlighted core targets such as CASP3, CCL5, SRC, PPARG, STAT1, MMP9, EGFR, IL2, ESR1, and AKT1. KEGG pathway enrichment analysis unveiled relevant pathways, including proteoglycans in cancer and Th17 cell differentiation. The network pharmacology study and molecular docking method shows multi-target pathway mechanism of triazole antifungal drugs.
