The effect of selective alpha-1 receptor antagonist on arterial stiffness parameters in patients with benign prostate hyperplasia

Purpose Non-selective adrenergic alpha-1 antagonists have been shown to reduce arterial stiffness. Our aim is to assess effects of selective adrenergic alpha-1 antagonist on arterial stiffness, namely silodosin. Methods This prospective study was carried out on 20 patients with recently diagnosed benign prostate hyperplasia. International Prostate Symptom Score calculation, arterial stiffness test with arteriograph and uroflowmetry were performed prior to planned silodosin medical treatment. After initial assessment, patients were given 8 mg of silodosin daily. Initial tests and calculations were repeated after 1 month of follow up. Comparisons between baseline and control data were performed using paired sample t-test and Wilcoxon signed-rank test for normally and non-normally distributed data respectively. Results There were significant reduction in International Prostate Symptom Scores of patients before and after silodosin treatment (p < 0.001). There were statistically insignificant reduction of arterial stiffness and increase of maximum flow rate (p = 0.314 and p = 0.053 respectively). Conclusion Although arterial stiffness parameters of our patients showed a trend of decrease with usage of silodosin, it did not reach statistical significance.