Relation Between Albumin multiply by high-density lipoprotein cholesterol and severity of coronary stenosis

Objective The relationship between serum albumin (ALB), high-density lipoprotein (HDL-c) and cardiovascular events is well established. However, few studies have explored the relationship between these two indicators in combination and CHD. Therefore, we will explore its association with the degree of coronary heart disease and predict the severity of coronary artery stenosis in patients with coronary heart disease. Methods We included 937 patients who underwent coronary angiography and reviewed their general conditions and laboratory test results for retrospective analysis. According to Gensini score, CHD patients were divided into mild, moderate and severe coronary artery stenosis, and Spearman correlation analysis was used to detect the relationship between serum indicators and the severity of coronary artery stenosis. Logistic regression analysis was used to determine the factors affecting the severity of coronary artery disease. Results Compared with the control group, the level of ALB*HDL-c in the CHD group was lower than that in the control group (P < 0.05). Compared with the subgroups of coronary artery disease, the severe disease group differed greatly from the other three groups as the degree of coronary disease increased. Gensini score was negatively correlated with ALB*HDL-c. Multiple regression analysis showed that ALB*HDL-c was significantly correlated with coronary heart disease. ALB*HDL-c is an independent predictor of CHD. ROC analysis showed that the critical value of ALB*HDL-c to predict CHD was 40.599, the sensitivity of 84.1% and the Yoden index of 0.475 could predict CHD, and the area under ROC curve was 0.804 (95% CI 0.772 to 0.837, P < 0.001). Conclusion ALB*HDL-c is an independent risk factor for CHD, which is closely related to coronary artery stenosis and can be used as an independent indicator of the severity of coronary artery stenosis.