Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms
This article has been Reviewed by the following groups
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- Evaluated articles (Rapid Reviews Infectious Diseases)
Abstract
Long-term sequelae after Coronavirus disease (COVID)-19 are frequent and of major concern. SARS-CoV-2 infection affects the host's gut microbiota, which is linked with disease severity in patients with COVID-19. We report here that the gut microbiota of post-COVID subjects had a remarkable predominance of Enterobacteriaceae strains with antibiotic-resistance phenotype compared to healthy controls. Additionally, short-chain fatty acids (SCFA) levels were reduced in their feces. Fecal transplant from post-COVID subjects to germ-free mice led to lung inflammation and worst outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae. Transplanted mice also had poorer cognitive performance. Overall, we show prolonged impacts of SARS-CoV-2 infection in the gut microbiota that persist after subjects have cleared the virus. Together, these data demonstrate that the gut microbiota can directly contribute to post-COVID sequelae, suggesting that it may be a potential therapeutic target.
Article activity feed
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Luis Vitetta
Review 2: "Gut Microbiota from Patients with COVID-19 Cause Alterations in Mice that Resemble Post-COVID Symptoms"
The reviewers found this study to be reliable and that its findings suggest interventions targeting gut microbiota may be a potential treatment for sequelae after COVID-19.
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Gucheng Zeng
Review 1: "Gut Microbiota from Patients with COVID-19 Cause Alterations in Mice that Resemble Post-COVID Symptoms"
The reviewers found this study to be reliable and that its findings suggest interventions targeting gut microbiota may be a potential treatment for sequelae after COVID-19.
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Strength of evidence
Reviewers: G Zeng (Sun Yat-sen University) | 📗📗📗📗◻️
L Vitetta (The University of Sydney) | 📗📗📗📗◻️ -
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