Sleep in progressive supranuclear palsy: A systematic review and meta-analysis of polysomnographic findings
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Purpose To evaluate polysomnographic measured sleep changes in patients with progressive supranuclear palsy (PSP) compared with controls. Methods MEDLINE, EMBASE, All EBM databases, and Web of Science were searched. Eight studies were included in the quantitative meta-analysis, involving 183 individuals with PSP and 158 controls. Results Meta-analyses revealed reduced sleep efficiency, total sleep time, and rapid eye movement (REM) sleep percentage, and increased wake time after sleep onset, N1 sleep percentage, REM latency, and apnea hypopnea index in PSP patients compared with controls. No significant group differences were observed in sleep latency, N2 sleep percentage, N3 sleep percentage, or arousal index. Conclusions Our meta-analysis found that multiple objective sleep abnormalities are present in individuals with PSP compared with controls. This suggests the potential value of polysomnography in characterizing sleep disturbances in PSP. These findings might be useful for distinguishing PSP from other neurodegenerative diseases. Future research should explore the effects of clinical characteristics (i.e., disease duration, disease severity, and comorbid sleep disorders) on sleep in PSP.
