Combining ultra-flexible electrodes with two-photon imaging to illuminate brain-wide neural dynamics

  1. Adrian Roggenbach
  2. Linus Meienberg
  3. Tansel Yasar
  4. Peter Gombkoto
  5. Nicolas Junghanns
  6. Wolfger von der Behrens
  7. Mehmet Yanik
  8. Fritjof Helmchen
  9. Christopher Lewis
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Abstract

Brain activity consists of neural signals dynamically coordinated across spatial and temporal scales. To sample distributed brain-wide activity, we combine chronically implanted ultra-flexible electrodes for subcortical recordings with simultaneous two-photon calcium imaging in mouse neocortex. Flexible electrodes preserve optical access even at steep insertion angles and enable weeks-long single-neuron tracking. With these combined recordings, we demonstrate how subcortical-cortical coupling is modulated across slow brain states and around fast ripple events.

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  1. Version published to 10.21203/rs.3.rs-10218667/v1 on Research Square