Efficacy and safety of antibiotic agents in children with COVID-19: a rapid review

  1. on behalf of COVID-19 Evidence and Recommendations Working Group
  2. Jianjian Wang
  3. Yuyi Tang
  4. Yanfang Ma
  5. Qi Zhou
  6. Weiguo Li
  7. Muna Baskota
  8. Yinmei Yang
  9. Xingmei Wang
  10. Qingyuan Li
  11. Xufei Luo
  12. Toshio Fukuoka
  13. Hyeong Sik Ahn
  14. Myeong Soo Lee
  15. Zhengxiu Luo
  16. Enmei Liu
  17. Yaolong Chen

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    SciScore for 10.1101/2020.04.13.20064402: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    searched: Cochrane library, MEDLINE (via PubMed), Embase, Web of Science, CBM (China Biology Medicine disc),
    Cochrane library
    suggested: (Cochrane Library, RRID:SCR_013000)
    MEDLINE
    suggested: (MEDLINE, RRID:SCR_002185)
    PubMed
    suggested: (PubMed, RRID:SCR_004846)
    Embase
    suggested: (EMBASE, RRID:SCR_001650)
    We also searched clinical trial registry platforms (the World Health Organization Clinical Trials Registry Platform (http://www.who.int/ictrp/en/), US National Institutes of Health Trials Register (https://clinicaltrials.gov/), ISRCTN Register (
    http://www.who.int/ictrp/en/
    suggested: (WHO International Clinical Trials Registry Platform, RRID:SCR_004475)
    https://clinicaltrials.gov/
    suggested: (ClinicalTrials.gov, RRID:SCR_002309)
    , 2020 through Google Scholar.
    Google Scholar
    suggested: (Google Scholar, RRID:SCR_008878)
    We used the bibliographic software EndNote.
    EndNote
    suggested: (EndNote, RRID:SCR_014001)
    Risk of bias assessment: We applied the Cochrane risk-of-bias (RoB) tool (22) for RCTs, Newcastle-Ottawa Scale(NOS) (23,24) for cohort studies and case-control studies, and the criteria recommended by the National Institute of Health and Clinical Optimization (NICE) for case series to assess the risk of bias (25).
    Cochrane risk-of-bias
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.21037/atm-20-3300
  3. Version published to 10.1101/2020.04.13.20064402v1 on medRxiv