The association between statin and COVID-19 adverse outcomes: national COVID-19 cohort in South Korea
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SciScore for 10.1101/2021.07.30.21261329: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: This study was approved by the Human Investigation Review Board of Public Institutional Bioethics Committee designated by the South Korean Ministry of Health and Welfare, which waived the requirement of informed consent due to retrospective study design and anonymity of the HIRA database (IRB # P01-2020-1262-001).
Consent: This study was approved by the Human Investigation Review Board of Public Institutional Bioethics Committee designated by the South Korean Ministry of Health and Welfare, which waived the requirement of informed consent due to retrospective study design and anonymity of the HIRA database (IRB # P01-2020-1262-001).Sex as a biological variable not detected. Randomization n… SciScore for 10.1101/2021.07.30.21261329: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: This study was approved by the Human Investigation Review Board of Public Institutional Bioethics Committee designated by the South Korean Ministry of Health and Welfare, which waived the requirement of informed consent due to retrospective study design and anonymity of the HIRA database (IRB # P01-2020-1262-001).
Consent: This study was approved by the Human Investigation Review Board of Public Institutional Bioethics Committee designated by the South Korean Ministry of Health and Welfare, which waived the requirement of informed consent due to retrospective study design and anonymity of the HIRA database (IRB # P01-2020-1262-001).Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There are also several limitations of this study. First, there may have been outcome misclassification in cardiovascular outcome (MI, stroke, and TIA), because we defined our cardiovascular outcome variables by diagnostic codes in admirative claim data. HIRA reported that 82% of primary diagnosis codes in claims coincide with electronic medical records,29 so more than 18% of outcome misclassification can occur while trying to capture all the diagnostic codes other than primary diagnosis codes. However, we expect a greater validity for MI, stroke, and TIA since our study population focused on hospitalized patients under careful management. Other outcomes such as all-cause death seem to be well classified because the HIRA COVID-19 database was linked to the national death records and outcomes defined from procedure codes (ICU admission and mechanical ventilation use) are also expected to be valid since the codes are mandatory in the reimbursement review process. Second, statin exposure was defined based on inpatient and outpatient prescription. We are not aware of detailed information on the exposure, for example, adherence to the prescription. Last, although we performed IPTW and thorough sensitivity analyses, due to the inherent limitation of claims data, there might be still a residual confounding by potential unmeasured confounders typically used in clinical studies (e.g., body mass index, baseline blood pressures, laboratory test values). In conclusion, our analysis of a n...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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