Eudragit-Based Nanoparticles for Oral Drug Delivery

Oral drug delivery remains the most preferred route of administration; however, traditional oral dosage forms face several limitations, including low bioavailability, enzymatic degradation, poor permeability, and lack of site-specific drug release. Recent advances in nanotechnology have introduced nanoparticles as promising drug carriers capable of overcoming these challenges. Eudragit-based nanoparticles have demonstrated great potential in enhancing drug stability, controlling release profiles, and improving site-specific targeting in the gastrointestinal tract. These polymethacrylate copolymers exhibit pH-dependent solubility, mucoadhesive properties, and tuneable drug-loading capacities, making them highly suitable for advanced oral formulations. This review provides a comprehensive analysis of Eudragit®-based nanoparticulate systems for oral drug delivery, discussing their formulations, physicochemical properties, and mechanisms of controlled drug release. Emphasis is placed on controlled-release strategies, targeted delivery, and the impact of polymeric materials in optimising therapeutic outcomes. By exploring these aspects, this review aims to highlight the potential of Eudragit-based nanoparticles as a robust platform for improving oral drug bioavailability and efficacy.