Response of Extensive Fungal Infection of the Sole of Feet, Palms, and Nails to Low-Dose Food-Grade Hydrogen Peroxide: A Case Report

Fungal infections remain a major global health challenge, especially when they are long-lasting and resistant to treatment. Previous findings suggested that very dilute, low-dose food-grade hydrogen peroxide (FGHP) at 0.5% and 1% concentrations could be both effective and safe in treating chronic fungal nail infections, even in cases lasting over two decades. These earlier outcomes indicated that hydrogen peroxide might help eliminate fungi and promote nail regeneration. In this study, researchers examined a 45-year-old woman with severe, treatment-resistant fungal infections affecting her palms, soles (with ulcerations), and multiple finger and toenails. Her condition had not improved despite treatment at three hospitals in Accra, Ghana. After informed consent, she was treated with FGHP: 40 ml of 0.5% solution three times daily for one month, followed by 1% for another month, then back to 0.5% for a third month. This three-month cycle was repeated three times over nine months, with one-month breaks between cycles. After sixteen months, her condition improved significantly. The ulcers healed completely, infections cleared from her palms and soles, and most nails regenerated. No adverse effects were reported, suggesting FGHP was both effective and safe. Studies are needed to establish the pharmacokinetics and appropriate dose of FGHP.