Optimizing Interprofessional Syphilis Care Through a Digital Decision Tool

Syphilis incidence has increased globally in recent years, affecting populations historically considered at lower risk, including heterosexual women. The clinical and serological complexity of syphilis presents important challenges for frontline clinicians, particularly in primary care and nurse-led sexual health settings. In increasingly interprofessional care environments, where nurses, physicians, pharmacists, and other health professionals share responsibilities for screening and treatment, standardized decision-making support is essential. To address these needs, we developed an open-access electronic clinical decision support tool specifically designed to assist clinicians in the evaluation, staging, and management of suspected or confirmed syphilis at the point of care. Built from current evidence-based guidelines, the tool translates existing recommendations into an interactive algorithm aligned with real-world clinical reasoning. This article describes the clinical context that motivated the tool’s development, its structure, and its potential role in supporting standardized, evidence-based care across diverse interprofessional clinical settings.