Psychological Burden and Quality of Life After Pediatric Liver Transplantation: A Cross-Sectional Study

Background/Objectives: Survival rates after pediatric liver transplantation have improved substantially over recent decades, yet the psychiatric consequences for recipients remain a concern that warrants closer attention. We sought to map the psychiatric symptom burden across multiple domains in this population and to determine which symptom clusters carry the greatest impact on health-related quality of life (HRQOL). Materials and Methods: Fifty liver transplant recipients between the ages of 8 and 16 were enrolled at a single center. Children and their parents completed four psychiatric measures—the CBCL, CDI, SCARED, and CRIES-13—alongside the parent-proxy PedsQL to capture HRQOL across physical, emotional, social, and school functioning domains. Correlations between instruments were calculated, and linear regression was used to determine which psychiatric variables independently predicted PedsQL Total scores. Results: Across all psychiatric measures, higher symptom scores were associated with lower HRQOL, with emotional functioning emerging as the most consistently affected domain. CBCL Total (r=−0.607), SCARED Total (r=−0.557), and CRIES-13 Total (r=−0.548) scores all correlated meaningfully with overall HRQOL. When entered into multivariable analysis, anxiety symptoms measured by the SCARED (β=−0.295, p=0.032) and post-traumatic stress symptoms measured by the CRIES-13 (β=−0.400, p=0.004) stood out as the two independent predictors of worse PedsQL Total scores. Conclusions: Even in medically stable recipients, anxiety and post-traumatic stress continue to weigh heavily on daily functioning and overall quality of life. These findings argue for integrating routine psychosocial screening and trauma-informed approaches into standard post-transplant care.