Postoperative Management with a Polyurethane Cup Containing an Oxygenated Oleic Matrix in Nipple‐Sparing Mastectomy with Immediate Reconstruction: A Single‐Centre Experience

Background: Nipple-sparing mastectomy with immediate reconstruction is a preferred option for selected patients undergoing prophylactic or therapeutic mastectomy. Optimizing postoperative wound care is essential to support healing, preserve the nipple–areola complex, and prevent delays in oncologic treatments. Objective: Our prospective observational study aims to evaluate the efficacy of the NovoX® CUP medical device in the dressing of post-NSM surgical wounds, evaluating clinical-surgical outcomes and the impact on QoL. Methods: We conducted a retrospective observational study on 54 patients who underwent NSM with immediate reconstruction at AOUI Verona between January 2025 and January 2026, Novox® Cup was applied intraoperatively and changed every 48 hours according to protocol. Surgeon-reported outcomes were assessed by Skin Flap Viability Scale and the complications by Clavien-Dindo classification. Patient-reported outcomes were assessed via the Wound-QoL17 questionnaire at 7, 30, and 90 days. Clinical outcomes were supported by photographic documentation. Results: Mean age was 51.5 years; BMI averaged 23.9 kg/m². Local complications occurred in 30.4% of cases (infections 12%, dehiscence 10%, seromas 4%). Mean healing time was 15 days, with 87.4% of patients having drains removed by day 14. One patient required surgical revision, and one (1.8%) experienced delayed adjuvant therapy. Wound-QoL17 responses showed minimal discomfort and high satisfaction. Clinical evaluation revealed favourable wound appearance and preserved NAC perfusion within 48 hours. Conclusions: Novox® Cup appears effective in supporting wound healing and NAC preservation after NSM, with high patient satisfaction and minimal treatment delays. Its integration into postoperative care may enhance outcomes and maintain oncologic timelines.