DAXX in Metabolic, Aging, and Immune Regulation: Recent Insights

Death domain-associated protein 6 (DAXX) was originally identified as a key regulator of Fas receptor-mediated apoptosis. Recent studies have found that it plays a central role in many biological processes, such as cell metabolism, aging and immunity. DAXX, through its nuclear localization and epigenetic regulatory capabilities, participates in the maintenance of metabolic homeostasis, DNA damage repair, and telomere stability, and modulates immune responses by regulating the transcriptional programs of immune-related genes. This review systematically discusses the molecular mechanisms and recent advances regarding DAXX's involvement in metabolism, aging, and immunity, and explores its potential as a therapeutic target, providing a theoretical basis for the study of related diseases and clinical interventions.