Beyond Fear Conditioning: Synaptic Pruning Dysregulation as the Core Pathogenetic Mechanism in Post-Traumatic Stress Disorder

For years, PTSD has been viewed mainly as something people "catch" after a bad experience, the result of an adult-onset failure in the brain's fear circuit. The standard story focuses on shaky extinction learning, a mis-tuned HPA axis, and glitches in glutamate-driven plasticity. Yet the newest, large-scale genetic studies paint a different picture. They show that the strongest polygenic signals sit not in classic glutamatergic genes but in the neuro-immune machinery that prunes synapses while the brain is still wiring itself. These signals hold up even after we account for every bit of shared variation with the glutamate system.Using MAGMA gene-set tests, partitioned heritability, and transcriptome-wide association built around the latest multi-ancestry GWAS of PTSD, we found repeatable, Bonferroni-safe enrichments in pruning regulators such as complement C4A, MHC-I gene HLA-B, the guidance cues SEMA3F and EFNA5, and the schizophrenia-linked transcription factors TCF4 and ERBB4. Together, the data point to what we call a "pruning-vulnerability cascade." First, genetically driven mis-pruning during sensitive windows leaves key circuits immature and easily rattled. Later trauma then overwhelms this shaky scaffold, setting off secondary failures in glutamate signalling and HPA feedback and locking them in through lasting epigenetic marks.Seeing PTSD as a problem that starts in development pulls together its early-life risk factors, the small hippocampi and other structural oddities on imaging, and its genetic overlap with disorders like schizophrenia. It also spotlights fresh prevention angles: for instance, dampening complement activity in young people who carry high pruning-risk profiles. To move from idea to intervention, we will need broad, multi-omic work in more diverse cohorts—but the roadmap is now clearer than ever.