Mitochondrial Stress in <em>Helicobacter pylori</em>-Associated Malignancies: A Review

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Abstract

Helicobacter pylori (H. pylori) infection is recognized as one of the most common bacterial infections worldwide. Its role in infection-associated cancers, such as in gastric cancer and MALT-lymphoma, is well known. Mitochondrial alterations in these malignancies are less documented. Mitochondria is a key organelle in maintaining cellular homeostasis under normal and pathological conditions. They regulate complex cellular processes, and they are key players in carcinogenesis and cancer progression in these H.pylori-associated malignancies. In this review, we summarize the role of mitochondrial stress in H. pylori infection, in gastric cancer, and MALT-lymphoma.

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