Vibrational Sonification and Visual Sigil of Zwitterionic Glycine as a Prototype Audio-Visual Stimulus for Human Sleep Thermoregulation

Glycine has been proposed as a temperature linked neuromodulator of human sleep, acting through nitric oxide mediated vasodilation and peripheral heat loss. Several small randomized trials suggest that pre-sleep oral glycine can modestly improve subjective sleep quality and next-day performance, but the mechanistic bridge between molecular structure, thermoregulation, and sleep remains largely untested. This study develops and documents a non-chemical representation of glycine that can be used as a prototype stimulus for future experiments. We first assembled a zwitterionic vibrational model of glycine from infrared and Raman data, and linearly mapped each normal mode from wavenumber to audio frequency so that 1600 cm-1 corresponds to 300 Hz, preserving the relative spectral pattern. On this fixed molecular spectrum we constructed two complementary 5 minute audio stimuli. The primary research stimulus applies a compressed oral like pharmacokinetic envelope to all modes, using a one compartment absorption elimination curve with parameters derived from published human glycine half life estimates and explicitly treated as order of magnitude constraints rather than precise population kinetics. In parallel, we generated an artistic evaporation reference in which higher frequency modes fade earlier than lower skeletal modes, organized into four qualitative stages that were designed by chemical intuition rather than fitted to data. Finally, we encoded the same vibrational groups in a concentric visual sigil and a short animation that can be paired with the audio. Together, these open source tools provide a transparent, molecule linked prototype for testing whether structure derived audio patterns influence thermoregulation, sleep related physiology, or subjective experience in future ethically reviewed studies. No new human or animal data are collected in this work; all clinical information is drawn from published trials, and the audio-visual materials are presented as a design prototype for future ethically reviewed studies.