Connecting the Dots between Hypermobile Ehlers-Danlos-Syndrome, Abnormal Fascia, Lymphatic and Glymphatic System Impairment, Craniocervical Instability, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID

Interdisciplinary research is needed on the biomechanical and structural pathways that might explain why people with connective tissue disorders like hypermobile Ehlers-Danlos Syndrome (hEDS) are particularly susceptible to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and ME/CFS-like presentations of Long COVID. In particular, research is needed on the role that disordered fascia and lymphatic system dysfunction might play in the pathophysiology of ME/CFS and Long COVID. Research is also needed on the role that spinal conditions like craniocervical instability and Chiari Malformation might play in obstructing outflow from the glymphatic system.