Individual-Level Behavioral Dataset Linking Trace Eyeblink Conditioning, Contextual Fear Memory, and Home-Cage Activities in rTg4510 and Wild-Type Mice with Doxycycline Treatment

This dataset provides synchronized multimodal behavioral measurements from 36 mice across four experimental groups: wild-type and rTg4510 tauopathy mice, each tested with or without doxycycline-mediated suppression of mutant tau expression. At six months of age, all animals underwent three standardized behavioral paradigms: home-cage monitoring, ten-day trace eyeblink conditioning, and contextual fear conditioning. Individual-level data include locomotor activity, rearing duration, conditioned response metrics, eyelid closure latencies, and contextual freezing percentages. All measurements are linked by unique mouse identifiers, enabling cross-task analyses without preprocessing or imputation. The dataset is accompanied by a complete data dictionary, processing workflow diagram, and validation analyses demonstrating cross-paradigm correlations. Cross-task associations are illustrated in main figures, with additional early-phase acquisition and temporal processing correlations provided in supplementary appendices. Provided in open CSV format with detailed metadata, this resource supports behavioral phenotyping, machine learning applications, and investigations of learning mechanisms in tauopathy models.