Synergistic Effects of Sodium Lauryl Sulfate and Lauryl Dime-Thylamine Oxide Blends on Foam Properties and Skin Irritation Reduction

Surfactants are commonly employed in cleaning, cosmetic and pharmaceutical formula-tions due to their ability to lower surface tension and facilitate the formation of emulsions, foams, and dispersions. Recent research highlights the advantages of synergistic interac-tions between anionic and nonionic surfactants to improve overall performance. In this study the physicochemical properties and performance of binary mixtures of the anionic surfactant sodium lauryl sulfate (SLS) and the amphoteric surfactant lauryl dimethyl amine oxide (LDAO) at varying ratios (100% SLS, 90:10, 80:20, 70:30, 60:40, and 50:50) were investigated. Key parameters analysed included critical micelle concentration (CMC), surface tension (), foam volume and potential irritability, assessed via the Zein test. The results revealed a clear synergistic effect between SLS and LDAO: all mixtures showed reduced CMC and minimum surface tension compared to the individual surfac-tants, while exhibiting enhanced foam volume and stability. Regarding irritability, in-creasing LDAO content consistently led to decreased protein denaturation, indicating lower irritancy levels. Furthermore, the results obtained in the Zein test confirmed that mixtures induced less protein denaturation than the sum of their individual surfactant components, with formulations ranging from moderately to non-irritating. The results obtained indicate that the more stable mixed micelle systems (SLS+LDAO) might improve the performance of cleaning formulations (, CMC, foam) while reducing the irritability.