Specialized Nursing-Led Interventions for Bladder Cancer Management: A Comprehensive Review of Evidence and Clinical Outcomes

Bladder cancer (BC) represents a significant global health burden, ranking as the tenth most commonly diagnosed malignancy worldwide, with an incidence rate of 5.6 per 100,000 person-years annually. This comprehensive review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology to search four databases from January 2018 to November 2025 summarizes evidence on specialized nursing-led interventions for bladder cancer management across the disease continuum. This concise but informative systematic review of 20 studies revealed substantial clinical and patient-reported benefits from specialized nursing interventions. Enhanced recovery after surgery (ERAS) protocols incorporating structured nursing care demonstrated a 35% reduction in postoperative complications. Integrated nursing interventions during post-operative intravesical therapy significantly improved patient satisfaction (P ˂ 0.001), treatment compliance (100 vs. 84%), and self-efficacy, while reducing anxiety and de-pression (P ˂ 0.001). Digital health platforms, including internet based and mobile ap-plications, proved effective in reducing caregiver burden, enhancing disease knowledge, and improving coping strategies. Preoperative stoma education and postoperative osto-my care management significantly improved self-efficacy, stoma care knowledge (Co-hen’s d=1.60; P ˂0.001), and overall health-related quality of life. Psychosocial interven-tions, including cognitive behavioral therapy and mindfulness-based approaches, demonstrated significant improvements in quality of life and reductions in fear of recur-rence, depression, and anxiety. However, a critical evidence gap exists regarding bladder cancer-specific mental health interventions. This review demonstrates that specialized nursing led care significantly improves clinical outcomes, patient satisfaction, symptom management, and quality of life across all phases of bladder cancer care, while reducing caregiver burden and enhancing psychological well-being.