The Integration Breakthrough: Sequenced Rapamycin, Senolytics, and NAD+ Boosters for Enhanced Anti-Aging Based on Cellular Energy Principles

The order in which anti-aging interventions are administered determines their effectiveness. This paper identifies a specific twelve-week sequence—NAD+ restoration followed by rapamycin followed by senolytics—that outperforms simultaneous administration of the same compounds. The sequence succeeds because aged cells lack the energy reserves to execute multiple repair processes simultaneously. NAD+ restoration rebuilds cellular energy capacity. Rapamycin activates autophagy once energy is available. Senolytics eliminate senescent cells once the tissue can process the resulting debris. Each phase prepares the cellular environment for the next. Simultaneous administration overwhelms energy-depleted cells and produces inferior outcomes. This finding reframes combination longevity therapy: intervention sequence matters as much as intervention selection.