Cycloruthenated Imines: A Step into the Nanomolar Region

  1. Arsenii A. Vasil’ev
  2. Ivan I. Troshin
  3. Pavel G. Shangin
  4. Ksenia M. Voroshilkina
  5. Ilya A. Shutkov
  6. Alexey A. Nazarov
  7. Aleksei V. Medved'ko
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Abstract

A new series of promising and easily accessible antiproliferative agents based on cy-cloruthenated imines of benzene and thiophene carbaldehydes has been developed and fully characterized using UV-Vis spectroscopy, X-ray diffraction, NMR, HRMS, and cyclic voltammetry. The biological activity of these compounds was tested against A2780, cis-platin-resistant A2780, and HEK293 cell lines, and they exhibited nanomolar IC50 values. They also showed a selectivity index of up to 2.5, indicating their potential as promising antiproliferative compounds.

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  1. Version published to 10.20944/preprints202512.0562.v1