Inactivation of BAP1 and the Hippo Pathway Defines the Mutational Landscape of Peritoneal Mesothelioma

Background: Peritoneal mesothelioma is a rare malignancy characterized by limited therapeutic options and poor prognosis. Genomic characterization can enhance the un-derstanding of the molecular mechanisms that lead to this disease, and can contribute to improved survival outcomes through therapeutic targets. Methods: Analysis was per-formed using a dataset from the American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE)® database. Data was analyzed to find statistically significant patterns in the genomic data, histological subtype, and clinical demographics. Results: Through the dataset results we found that the most common somatic mutation was found in the BAP1 gene (25.98%). Other common mutations were found in the NF2 (15.19%), TP53 (9.3%) and SETD2 (8.3%) genes. Several pathways were found as potential treatment targets. This includes the chromatin re-modeling, Hippo, and p53 signaling pathways. Given the size of our dataset, we were unable to draw significant conclusions about certain demographics. Conclusions: This study presents data that can help draw conclusions on common mutations, mutual ex-clusivity patterns, and demographics at risk for peritoneal mesothelioma. Looking into peritoneal mesothelioma genomic datasets can provide insight which may help develop possible intervention targets for therapeutic treatment.