Novel Nutraceutical Combination Restores Hepatic Deiodinase Activity Under Inflammatory Conditions: Evidence from an In Vitro Model

Tyroid hormones ,are key regulators of energy metabolism, involeved in a systemic conversion of T4 to T3. This reaction is catalyzed by selenoprotein iodothyronine deiodinase type 1 (DIO1). DIO1 protein is overexpressed in the liver and kidney tissue and it is regulated by nutritional factor, cytokines and oxidative stress. The present study aimed to explore, in an in vitro model of LPS-induced inflammation, the effects of a combination of selected nutrients—vitamin A, selenium, taurine, oleic acid, and resveratrol—on the expression and activity of DIO1 (Type 1 Iodothyronine Deiodinase) in Hepatoma cancer cells (HEPG2). The objective was to determine whether these bioactive compounds could mitigate inflammation-induced suppression of peripheral thyroid hormone activation, thereby supporting a more favorable redox and metabolic profile.To summarize, simoltaneous treatment with taurine, resveratrol, oleic acid and vitamin A not only prevents DIO-1 suppression, but also positively regulates its levels of expression offering a promising avenue for maintaining endocrine and metabolic health in frail, elderly, or oncologic patients and potentially across a broader spectrum of chronic inflammatory conditions.