Economic and Humanistic Burden of Multimorbidity in the United States: A Longitudinal Study of Expenditure and Quality of Life Trajectories, 2019–2022

This study examines the economic and humanistic burden associated with multimorbidity among adults in the United States. Using data from the 2019–2022 Medical Expenditure Panel Survey (MEPS), we identified individuals with two or more chronic conditions and assessed trends in health care expenditures, out-of-pocket costs, inpatient stays, and health-related quality of life (HRQL). Weighted analyses were conducted to estimate national patterns and annual changes across survey years. Mean adjusted total and out-of-pocket expenditures, inpatient visits, and mental HRQL scores were compared using regression models controlling for sociodemographic and health factors. Findings showed that multimorbidity was associated with substantial economic burden, reflected in higher healthcare costs and out-of-pocket spending over time. HRQL consistently declined across the study years, highlighting the growing humanistic toll of chronic disease clustering. These patterns underscore the need for policies that promote integrated care models, chronic disease prevention, and financial protection strategies for adults with multiple conditions. The results provide timely evidence for health policymakers and practitioners seeking to improve health system efficiency and equity in managing multimorbidity.