Comparison of the Effectiveness of Three Different Combinations for Colonoscopy Preparation

Background/Objectives: High-quality bowel preparation is essential for the diagnostic accuracy of colonoscopy, which remains the gold standard for colorectal cancer screening. Aims: In our study, we aimed to compare the efficacy and tolerability of three bowel preparation regimens—Moviprep with Donat Mg, Plenvu, and Plenvu with Donat Mg—commonly used in clinical practice in Slovenia. Methods: We conducted a randomized, multicenter, prospective study across three Slovenian gastroenterology centers. A total of 300 patients undergoing elective colonoscopy were randomly assigned to one of the three bowel preparation groups. Bowel cleanliness was evaluated using the Boston Bowel Preparation Scale, and lesion detection was assessed using polyp detection rate (PDR) and adenoma detection rate (ADR). Patients also completed a questionnaire assessing adverse effects, overall tolerability, and willingness to repeat the same regimen. Statistical analyses included ANOVA, chi-square, Kruskal-Wallis, and t-tests. Results: All three regimens achieved high bowel preparation adequacy (≥95%), with no statistically significant differences in total BBPS scores, PDR, or ADR. Adverse effects were mild and comparable between groups, with thirst and bloating being the most frequently reported symptoms. Patient satisfaction and willingness to repeat the preparation were high across all regimens, with no significant differences. Conclusions: Moviprep with Donat Mg, Plenvu, and Plenvu with Donat Mg are all effective, safe, and well-tolerated bowel preparation regimens. Each achieved a high level of bowel cleanliness and lesion detection, exceeding ESGE minimum standards. Their comparable efficacy and tolerability support their interchangeable use in routine colonoscopy practice.