Health-Related Quality of Life in People with Relapsing-Remitting Multiple Sclerosis: A Prospective Observational Study

Background: Relapsing-remitting multiple sclerosis is a chronic neurological disease that affects the central nervous system, with a significant impact on health-related quality of life. Main: To determine the sociodemographic, clinical, and quality of life characteristics, establish relationships, and identify predictive factors for quality of life. Methods: An observational, analytical, and prospective study was conducted with 35 participants diagnosed with relapsing-remitting multiple sclerosis at the Lucus Augusti University Hospital between January 2023 and March 2025. The MSQOL-54 questionnaire was used to assess quality of life and its dimensions at diagnosis, three months, and six months. Data were analyzed using non-parametric tests with SPSS v24 software. Results: Perceived quality of life demonstrated overall stability (mean score of 62 points), although dimensions such as emotional limitations and social functioning worsened. Factors such as family history, autoimmune diseases, and lifestyle habits were significantly associated with quality of life. Initial quality of life was found to predict its future trajectory. Conclusion: Quality of life among individuals with relapsing-remitting multiple sclerosis remains generally stable, though certain dimensions tend to deteriorate. Early and multidimensional interventions could mitigate the cumulative impact of the disease and improve perceived quality of life, particularly in emotional and social domains.