Single-Pill Combination of Perindopril-Indapamide-Amlodipine in Hypertensive Patients with Obesity: Long-Term Efficacy

Background and Objectives: Treatment of patients with arterial hypertension (H) associated with abdominal obesity (O) is complex and most often requires the use of several antihypertensive agents. The purpose of the work: to evaluate the advantages of the single pill combination (SPC) of perindopril (P), indapamide (I) and amlodipine (A) in comparison with their free combination (FC) in achieving effective control of H for a long time in patients with O. Materials and Methods: Seventy five patients (of which 45 men) with uncontrolled H associated with O (age 48-66 years) were examined. Among patients included in the study, 45 received a FC of P, I and A, and 36 - SPC of these drugs. The drugs were used once a day in the following daily doses: P-4-8 mg, I-1.25-2.5 mg and A-5-10 mg. Patients were followed up for 12 months. Results: SPC of P,I and A were significantly more effective than FC in hypertensive patients with O. The high efficiency of SPC persisted for a long time (over 12 months) and associated with significantly increased adherence to therapy in comparison with FC. To achieve target BP levels with SPC, lower doses of drugs were required than with FC. Conclusion: The single pill combination of P, I and A shows greater efficiency than FC, and makes it possible to maintain BP within the target levels for a long time with lower doses of drugs.