Relationship Between Metabolic Indicators and Bone Mineral Density in Older Men―A 4-Year Longitudinal Study―

Background: The bone mineral density is closely related to the risk of fracture, and maintaining the bone mineral density is important for maintaining health in older adults. Metabolic syndrome has been shown to be related to fracture, and the associations between metabolic indicators and reduced bone mineral density have been established. However, few studies have investigated bone mineral density or osteoporosis in men. Aim: In this study, we examined whether metabolic indicators and their changes over four years are associated with a decline in bone mineral density in men aged 65 and older. Methods: A total of 86 community-dwelling men aged ≥65 years from M City and O Town who participated in health check-ups were included. all subjects were examined twice (first and 4 years later) for or physical characteristics (height, body weight, BMI) and blood markers of metabolic syndrome. Statistical analysis: The multiple regression analysis was conducted by considering the baseline indicators of metabolic syndrome. BMD (g/cm²) was set as the objective variable. Additionally, another multiple regression analysis was performed by considering changes in the indicators of metabolic syndrome over four years. In this analysis, BMD (g/cm²) was set as the objective variable. Results: As a result, the bone mineral density after 4 years was negatively correlated with baseline systolic blood pressure and HbA1c levels during after 4 years. Conclusions: Thus, it is important to prevent hypertension and elevation of HbA1c by an appropriate lifestyle for maintaining a high bone mineral density.