Analysis of the Association Between Platelet Count and HbA1c in Non-Diabetic Middle-Aged and Older Adults in China

Background: Platelet activation and aggregation play a critical role in thrombotic events among individuals with diabetes. HbA1c is widely utilized for assessing long-term blood glucose control, with higher levels being associated with increased mortality and prevalence of cardiovascular disease. This study aims to investigate the correlation between platelet counts and HbA1c levels in non-diabetic middle-aged and older adults.Method: Multivariate logistic regression analyses were conducted on 3940 subjects from the China Health and Retirement Longitudinal Study (CHARLS) to investigate the association between platelet count and HbA1c levels. T-tests, F-tests, and Chi-square tests were used to compare baseline characteristics of platelet count and HbA1c for statistical differences. Finally, multivariable-adjusted logistic regression models were employed to examine the odds ratio for their association.Results: The mean and standard deviation of platelet count were 206.32±71.3 mg/dl for males and 219.89±75.83 mg/dl for females. The mean and standard deviation of HbA1c (%) in females were 5.08±0.41 and 5.08±0.40, respectively. Compared to the baseline platelet counts (platelets <164.00 mg/dl), we found a weak association between HbA1c and platelet levels among women. After adjusting for other confounding factors, we observed no correlation between platelet count and HbA1c levels.Conclusions: After thorough analysis, we have concluded that there is no significant correlation between platelet count and HbA1c levels in non-diabetic middle-aged and older adults in China. Our findings suggest that these two factors are not linked within this demographic. Our results provide valuable insights into the health of non-diabetic individuals in China, particularly those who are middle-aged or older.