Molecular Mechanisms of Tendinopathy: Unraveling the Pathogenesis of Tendon Diseases

Musculoskeletal injuries are common among dentists due to repetitive hand movements and prolonged 10static postures. Their work often requires bending, twisting, or holding awkward positions, which can strain 11the body, leading to muscle overuse and a higher risk of disorders. These issues may result in chronic pain, 12early retirement, or even permanent disabilities, impacting dental professionals worldwide. Tendinopathy, 13caused by overuse and strain, is now understood to be more complex. Tendon repair is a slow process influ- 14enced by health and age, progressing through three phases: inflammation right after injury, proliferation last- 15ing 3–4 weeks, and remodeling, which may take 1–2 years. Each phase involves specific cellular activities 16and biochemical pathways crucial for healing. Understanding the pathophysiology of musculoskeletal diseases 17is helping to develop more precise treatments. As insights into tendinopathy’s cellular and molecular mecha- 18nisms grow, targeted therapies are likely to improve. Patients' variations highlight the need for personalized 19treatment plans. Finally, the study emphasizes the importance of proactive measures like occupational health 20programs and ergonomic practices to support dentists’ well-being and career longevity.