Using Conjoint Analysis to Elicit Benefit-Risk Preferences for Different Treatment Options Among Psoriasis Patients Receiving Systemic Treatment

Background: Psoriasis has a huge impact on patient’s life. Treatment dissatisfaction and non-adherence are common among patients with psoriasis, partly due to discord-ance between individual preferences and recommended treatments. The modern strategy for psoriasis should be focused on human centric treatment that recognizes the needs and preferences of patients with a goal for safe, effective, quality, and ac-ceptable health services for a lifetime. The aim of this analysis was to capture patients’ preferences with moderate-to-severe psoriasis regarding various treatment attributes. Methods: Development of a specialized questionnaire containing four attributes with three levels each was used, followed by an orthogonal plan based on conjoint analysis. Nine combinations of therapeutic scenarios were produced as a result, to investigate participants’ preferences. Respondents were asked to rank alternatives from best to worst. Results: The risk of developing pneumonia or other serious infection within a decade, seems to affect more the overall preference of patients with an implied assigned value of 37. The second attribute was the type and frequency of the administration with a value of 27 followed by the treatment effectiveness with great improvement of body surface with a value of 25. The lowest utility (11) was sustainability of long-term re-mission of psoriasis. Conclusions: Psoriasis patients want safe, effective, and easy to administer treatments.