A Historical Revision on The Evolution of Purpura Fulminans Management Since 1995

Purpura fulminans (PF) is a life-threatening condition characterized by rapidly progressive skin necrosis, often resulting from severe infections or coagulopathy. Since 1995, the management of PF has evolved significantly, driven by advances in medical research, improved diagnostic techniques, and a better understanding of the underlying pathophysiology. This historical reflection examines the key developments in PF management over the past three decades, highlighting the shift from conventional therapeutic approaches to more targeted interventions. Early strategies primarily focused on aggressive supportive care and the use of broad-spectrum antibiotics. However, recent innovations have introduced specific therapies, including the use of anticoagulants and immunomodulatory agents, which address the coagulopathic component of the disease more effectively. Additionally, the role of multidisciplinary teams in managing PF has gained prominence, emphasizing the importance of collaborative care in improving patient outcomes. This review underscores the necessity for ongoing research and the integration of emerging technologies in the management of PF, aiming to enhance clinical practices and reduce morbidity and mortality associated with this severe condition. The evolution of PF management serves as a compelling case study in the broader context of critical care medicine, highlighting the importance of adapting treatment protocols to reflect new scientific insights and clinical experiences.